Review: 5-Fluorouracil cardiotoxicity: A critical review
نویسندگان
چکیده
منابع مشابه
5-fluorouracil induced cardiotoxicity: review of the literature.
5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk...
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Pyrimidine analogues such as 5-fluorouracil (5-FU) are widely used in adjuvant and palliative treatment of various solid tumours. However, their administration may be associated with severe adverse events such as myelosuppression, mucositis or cardiotoxicity. Cardiotoxicity is a relatively rare event but its fatal outcomes occur at a rate of 2.2-13.3%. Since 5-fluorouracil is widely used in med...
متن کامل5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
BACKGROUND Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly understood. CASE PRESENTATION A case of 5-fluorouracil-induced cardiotoxicity, possibly due to coronary artery spasm, and mimicking acute anterolateral myocardial infarction is presented and discussed. Electrocardiographs highli...
متن کاملCardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors.
PURPOSE To systematically review the incidence, manifestations and predisposing factors for cardiovascular toxicity in cancer patients treated with systemic 5-fluorouracil or capecitabine. DESIGN We searched PubMed, EMBASE and Web of science for studies with ≥ 20 cancer patients evaluating cardiovascular toxicity of 5-fluorouracil and capecitabine. We hand searched the reference lists of all ...
متن کاملIntralesional 5-fluorouracil in keloid treatment: a systematic review.
In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms "keloid" and "5-FU", together with all synonyms of the...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1990
ISSN: 0923-7534
DOI: 10.1093/oxfordjournals.annonc.a057793